- ??44???????????????γ???????????????
- ??MEMS?????????????????????-2022?桷
- ??43???????????????γ?????MEMS??????
- ?????崫???????????г?-2022?桷
- ??VCSEL?????????-2022?桷
- ?????????崫????SGP40?????????
- ??42???????????????γ???????????????????
- ??Merit Sensor???????????TR??У???MEMSо???HM??У??????????
- ??41???????????????γ??????????????????
- ??40???????????????γ????????????????
????????徹?汣????H3N2???????????
2022-07-23 21:45:18 ???????????? ?????0 ?????
??ó????100~1,000μm????????????????д??????????????????????????????????????????????????????????????????????о??????????о????????????????硣???????????MN?????????????????????о???Σ???????о????????????????IM????????????????????Ч??
?????????????????????????????????????????????о??????????????????????徹?汣????H3N2??????磬????о??????“Development of the H3N2 influenza microneedle vaccine for cross-protection against antigenic variants”???????Scientific Reports??????
????H3N2???????в????????????????о?????????H3N2?????????????????????棺??1?????????????2?????????????????汣???????????о??У???????????HA????????????????????壬????????????????????????????????????H3N2?????????????????????????????о??У??о?????????Ч???????HPLC??????H3N2??????????????÷??????????壬????????????????????????????????汣????
?1 ????HA??HPLC????????H3N2???в??????汣????H3N2??????翪??????
?2 H3N2??????????
????FITC???????????????????о???????????????????H3N2??????????????????????顣?????????15??330??????????????????????????????3a???????????????????????仯???仯???3b????????θ????30??60?????????????????????210????????????????????????????FITC-????????????????????????????????????????????ε?????????????????У?FITC-??????????С?????????????????С?
?3 ??a??????????????15??30??60??90??150??210??270??330???????????????????????????? = 200μm??????b????15??330????????????????????仯??
??????о???????ü????????????壬??H3N2??????????????汣????Ч??????????????????????仯????????о???19-20A/KS/17H3N2??????????2015-16??????H3N2???в?????С?????汣?????á??????????????????С?????????????????????????????IM?????????????????????Ч????????????????汣????Ч??????
?4 С??????????????BALB/cС????19-20A/KS/17H3N2??????磨3μg/С?????????????????????3μg/С???????????????????????3??????????15-16A/SW/13 H3N2???????С??
?5 ??a?????????15-16A/SW/13 H3N2????????????С??14???????仯???b??????????c???????A/PE/09 H3N2??A/TX/12 H3N2??A/SW/13 H3N2????14???19-20A/KS/17 H3N2??????????С???IM????С???С???????к????ζ????d???????A/PE/09 H3N2??A/TX/12 H3N2??A/SW/13 H3N2????14???19-20 A/KS/17 H3N2??????????С???IM????С??С??????????????HI???ζ??
???????????HPLC??????????????????????H3N2??????????????Ч???????????????????????????????
?????????https://doi.org/10.1038/s41598-022-16365-2
?????????
??????????????????????????????????????
???????????
??????????
???????????
- 601????????????????????
- 330?п???????????????????????????????????
- 319???????????????????????????????????????????
- 186????????MEMS?????????????????????
- 96????о???????????????????HIV??????????????
- 37????????????????????????????????
- 32???????????????????豸???????????е?????????
- 5????????????????????????????????